What DNA files do you accept?

We accept raw data exports from 23andMe (all versions), AncestryDNA, MyHeritage, LivingDNA, and FamilyTreeDNA. Files can be .txt, .csv, .tsv, .zip, or .gz format. Most consumer DNA chips contain 600K–900K variants.

How accurate are polygenic risk scores?

Every score uses peer-reviewed, published models from the PGS Catalog — the same database used by research hospitals. Each score shows its confidence level and the number of variants used. With deep imputation enabled, coverage jumps from ~30% to ~95%, making scores significantly more powerful. PRS show relative genetic risk compared to the population.

What happens to my DNA data after analysis?

Your DNA file is deleted immediately after analysis completes. All intermediate files are purged within 2 hours. You receive a SHA-256 Data Deletion Certificate proving destruction. We do not store, sell, or share your genetic data.

What’s included in the report?

2,800+ polygenic risk scores across cardiovascular, cancer, metabolic, neurological, and autoimmune categories. ClinVar pathogenic variant scanning. Pharmacogenomics (drug response) analysis. A personalized longevity protocol with actionable recommendations. All delivered as an interactive HTML report.

What is deep imputation?

Consumer DNA chips only test ~700K positions out of your 3 billion base pairs. Deep imputation uses the Beagle 5.5 reference panel to statistically infer the missing ~27 million variants. This dramatically improves the accuracy of polygenic risk scores, especially for conditions where key variants aren’t on the chip.

How long does analysis take?

Without imputation: 2–5 minutes. With deep imputation enabled: 15–45 minutes depending on server load. You’ll receive your report by email when it’s ready.

Is this a medical diagnostic tool?

No. Helix Sequencing is for research and educational purposes. Results should be discussed with a healthcare provider before making medical decisions. Polygenic risk scores show relative genetic predisposition, not diagnoses.

Can I compare my DNA with a family member?

Yes. Our DNA Compare feature lets you trace variant inheritance between two related individuals — see which alleles came from which parent, identify shared risk factors, and explore inherited traits side by side.

What questions can I ask an AI about my DNA?

You can ask about drug safety based on your metabolizer status (CYP2D6, CYP2C19, CYP3A4), disease risk from polygenic risk scores, supplement recommendations based on variants like MTHFR C677T, fitness optimization from muscle fiber and recovery genetics, and dietary guidance based on your methylation and detoxification gene variants.

Which AI assistants work with Helix Sequencing?

Claude by Anthropic supports MCP natively, allowing real-time queries against your genomic data. ChatGPT works via JSON export or plugin integration. Any AI assistant that accepts structured data input can use the Helix JSON export format.

How is this different from Bystro AI or other genomics chatbots?

Most genomics AI tools like Bystro are closed chatbots where you can only ask questions through their interface. Helix Sequencing gives you the data layer itself: a complete, structured genomic profile you can connect to any AI assistant of your choice. You are not locked into one chatbot. You bring your own AI.

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Connect Your DNA to AI Assistants

Your genome is the most personal dataset you own. Now you can connect it to the AI tools you already use — and get answers grounded in your actual genetic data.

Updated March 29, 2026 · 11 min read

What Does It Mean to Connect Your DNA to AI?

Connecting your DNA to an AI assistant means generating a comprehensive, structured genomic profile — including polygenic risk scores, pharmacogenomic metabolizer statuses, and clinically relevant variants — and making that data accessible to AI tools like ChatGPT and Claude so they can answer health questions using your actual genetic information instead of generic population-level advice.

Helix Sequencing makes this possible through two mechanisms: a JSON export of your complete genomic profile that you can upload to any AI assistant, and an MCP (Model Context Protocol) serverthat lets compatible AI assistants query your genetic data in real time. The result is the same — an AI that knows your genome and can reason about it when you ask questions about medications, disease risk, nutrition, or fitness.

This is not a hypothetical future feature. The Helix MCP server is built and operational, with tools for querying variants, polygenic risk scores, pharmacogenomics, gene-disease convergences, and inheritance patterns. Claude supports MCP natively. ChatGPT works through JSON export or plugin integration.

Why Your DNA Data Needs AI Context

Raw genetic data is meaningless without interpretation. A consumer DNA file contains hundreds of thousands of genotype calls — rows of chromosome positions and allele letters. Even a processed report with variant annotations and risk scores generates hundreds of pages of information. No one reads all of it. No one can hold it all in working memory while making a health decision.

This is where AI assistants fundamentally change the equation. Instead of reading a 200-page report looking for the one line relevant to a medication your doctor just prescribed, you ask: “My doctor prescribed codeine for pain. Is it safe given my CYP2D6 status?” The AI checks your pharmacogenomic profile, sees that you are a CYP2D6 ultrarapid metabolizer, and explains that codeine is converted to morphine faster in your body — potentially causing dangerous respiratory depression. That is actionable, personalized, and immediate.

Other questions become equally straightforward: “What supplements should I take based on my MTHFR variant?” The AI checks your MTHFR C677T status, sees you are homozygous TT, and recommends methylfolate over folic acid because your enzyme efficiency is reduced by approximately 70%. It cross-references your COMT and MTR variants to give a complete methylation picture rather than a single-gene answer.

The shift is fundamental: instead of you learning to read genetic reports, the AI reads the report and translates it into answers to the questions you actually have. Your genome becomes a queryable knowledge base, not a static PDF.

How It Works: Three Steps

Getting your DNA connected to an AI assistant takes minutes, not hours. Here is the process:

Upload your DNA file and get your full report

Upload your raw DNA file from 23andMe, AncestryDNA, or MyHeritage. Helix Sequencing runs deep imputation (expanding your data from ~700K to 28M+ variants), calculates 3,550+ polygenic risk scores from the PGS Catalog, analyzes 34 pharmacogenes across all major drug-metabolizing enzymes, and screens 400,000+ ClinVar variants for pathogenic and likely pathogenic findings.

Export your profile as JSON or connect via MCP

Download your complete genomic profile as structured JSON — a machine-readable file containing your PRS percentiles, pharmacogenomic statuses, flagged variants, and convergence analysis. Or, for real-time access, connect your AI assistant to Helix's MCP server using a personal API key. Claude supports MCP natively. ChatGPT works with the JSON export.

Ask your AI assistant health questions grounded in YOUR genome

Start asking questions. The AI no longer gives generic answers about 'people with this variant' — it gives specific answers about you. Ask about drug safety, cancer risk, supplement needs, training optimization, or dietary guidance. Every answer is grounded in your actual genotype data.

What You Can Ask Your AI About Your Genome

The power of connecting your DNA to an AI is best understood through specific examples. Here are real query patterns and how the AI resolves them against your genomic data:

"What medications should I be careful with?"

The AI checks your CYP2D6, CYP2C19, CYP3A4, CYP2C9, and other pharmacogene statuses. If you are a CYP2D6 poor metabolizer, it flags codeine, tramadol, and certain antidepressants. If CYP2C19 is rapid, it notes that clopidogrel (Plavix) works well but omeprazole may be less effective. This covers 34 pharmacogenes and hundreds of drug interactions.

"Design a meal plan for my methylation genes"

The AI examines your MTHFR (folate metabolism), COMT (catechol metabolism), MTR and MTRR (methionine synthase), and BHMT (betaine pathway) variants. It builds a nutrition plan emphasizing methylfolate-rich foods if MTHFR is impaired, manages methyl donor balance if COMT is slow, and adjusts B12 form recommendations based on your MTR status.

"What cancers am I at highest genetic risk for?"

The AI queries your polygenic risk scores across all cancer PRS models — breast, prostate, colorectal, lung, melanoma, bladder, pancreatic, and others. It ranks them by percentile, highlights any above the 80th percentile, and cross-references with relevant single-gene variants (BRCA1/2, Lynch syndrome genes, APC) from your ClinVar screening.

"Should I take folate supplements?"

The AI checks your MTHFR C677T and A1298C genotypes specifically. Homozygous C677T (TT) means roughly 70% reduced enzyme activity — methylfolate is strongly preferred over synthetic folic acid. Heterozygous (CT) means roughly 35% reduction. The AI explains the biochemistry and recommends a specific form and approximate dose range to discuss with your doctor.

"Optimize my training plan for my genetics"

The AI pulls your PRS data for VO2max potential, muscle fiber composition (fast-twitch vs slow-twitch proportion), injury recovery speed, tendon and ligament resilience, and exercise-induced inflammation response. It suggests whether your genetics favor endurance or power training, how much recovery time you likely need, and which injury types to proactively manage.

These are not hypothetical. Each query pattern maps to specific data fields in the Helix genomic profile. The AI does not guess — it references structured, typed data about your genotype.

MCP: The Protocol That Makes This Possible

Model Context Protocol (MCP)is an open standard that allows AI assistants to connect to external data sources and tools in real time. Think of it as a USB port for AI — a standardized way for an AI to reach out, query a service, and bring the results back into the conversation.

Helix Sequencing provides a dedicated MCP server that exposes your genomic data through a set of structured tools. When an AI assistant connects to the Helix MCP server using your personal API key, it gains access to the following query capabilities:

get_domain_brief

Retrieves a high-level summary of your genomic profile across all analyzed domains.

get_variants

Queries specific genetic variants by gene name, rsID, or clinical significance.

get_prs_scores

Returns your polygenic risk score percentiles for specific conditions or traits.

get_pharmacogenomics

Looks up your metabolizer status for specific drug-metabolizing enzymes.

get_convergences

Identifies where multiple genetic signals converge on the same disease or pathway.

get_evidence

Pulls the underlying evidence and citations for any flagged finding.

get_inheritance

Analyzes inheritance patterns for variants relevant to family planning.

The setup is straightforward: after your DNA analysis is complete, you generate a personal API key from your Helix dashboard. You add the Helix MCP server configuration to your AI assistant (Claude supports this natively in its settings). From that point forward, the AI can query your genomic data on demand during any conversation.

For ChatGPT and other assistants that do not yet support MCP natively, the JSON export provides the same data in a single file. You upload it to the conversation, and the AI can reference it throughout the session.

Privacy and Data Control

Sharing genetic data with an AI raises legitimate privacy questions. Helix Sequencing is designed around a principle of zero retention: your raw DNA file is processed and then deleted. What remains is a derived genomic profile — processed results, not raw genotype data.

When you use the JSON export, you have complete control over what you share. The file lives on your device. You choose when to upload it to a conversation and with which AI assistant. No data passes through Helix servers during this process.

When you use MCP, access is gated by your personal API key. The AI can only query the processed results you have authorized — never the underlying raw genotype data. If you want to revoke access, you invalidate your API key. Access stops immediately.

Raw DNA file is deleted after analysis. Zero retention.

JSON export stays on your device. You control where it goes.

MCP access is gated by a revocable API key you generate.

AI assistants only see processed results, never raw genotype data.

No genomic data is sold, shared, or used for advertising.

No Other Platform Does This

There are other companies working at the intersection of genomics and AI. Bystro AI, for example, offers an AI chatbot for genetic data interpretation. But there is a critical architectural difference: Bystro and similar tools are closed chatbots. You can only ask questions through their interface, using their model, within their constraints.

Helix Sequencing takes the opposite approach. Instead of locking you into one chatbot, Helix gives you the data layer itself— a complete, structured genomic profile that you can connect to any AI assistant of your choice. Prefer Claude for its reasoning depth? Use MCP. Prefer ChatGPT for its plugins? Use JSON export. Want to use a local model for maximum privacy? The JSON file works offline.

	Genomics Chatbot	Helix + Your AI
AI model	Their choice only	Any: Claude, ChatGPT, local models
Data access	Locked in their platform	JSON export or MCP — you own it
Query flexibility	Limited to built-in prompts	Ask anything in natural language
PRS coverage	Varies (often limited)	3,550+ PGS Catalog models
Pharmacogenes	Varies	34 genes, all major enzymes
Data retention	Stored on their servers	Zero retention. File deleted after analysis.

The principle is simple: you should own your genomic data and choose your own AI. Helix builds the data layer. You bring the intelligence layer.

Frequently Asked Questions

Can I connect my DNA data to ChatGPT?

Yes. Helix Sequencing lets you export your complete genomic profile as structured JSON, which you can upload directly to ChatGPT. The export includes polygenic risk scores, pharmacogenomics results, and clinically relevant variants in a format ChatGPT can parse and reason about.

What is MCP and how does it work with DNA data?

MCP (Model Context Protocol) is an open protocol that lets AI assistants query external data sources in real time. Helix provides an MCP server that AI assistants can connect to using your personal API key. This allows the AI to look up your specific variants, PRS percentiles, and pharmacogenomic status on demand rather than requiring a static file upload.

Is it safe to share my DNA data with an AI assistant?

Helix operates with zero data retention. Your raw DNA file is deleted after analysis. When using the JSON export, you control exactly what you share. When using MCP, your API key can be revoked at any time, and the AI only accesses processed results you authorize, never the raw genotype data.

Do I need whole genome sequencing for this to work?

No. A standard consumer DNA chip from 23andMe, AncestryDNA, or MyHeritage is sufficient. Helix runs deep imputation to expand your ~700,000 directly genotyped variants to over 28 million, providing comprehensive coverage for PRS calculation, pharmacogenomics, and variant screening.

Which AI assistants support MCP?

Claude by Anthropic supports MCP natively as of 2025. ChatGPT works through JSON export or plugin integration. The MCP standard is open and growing — additional AI assistants are expected to adopt it. Any assistant that accepts structured data can use the Helix JSON export today.

How is this different from asking ChatGPT about genetics without my data?

Without your data, an AI can only give generic answers: 'People with MTHFR C677T TT genotype should consider methylfolate.' With your data connected, the AI knows your actual genotype and gives specific answers: 'You are homozygous C677T TT, your COMT is Val/Val, and your MTR is normal — here is what that combination means for your methylation pathway.'

Connect Your Genome to AI Today

Upload your DNA file from 23andMe, AncestryDNA, or MyHeritage. Get your complete genomic profile with 3,550+ PRS models, 34 pharmacogenes, and 400,000+ variant screenings. Export as JSON or connect via MCP to start asking your AI real questions about your health.

Upload Your DNA File

No account required. Zero data retention. Your file is deleted after analysis.

Key Takeaways

Helix Sequencing lets you connect your genomic data to AI assistants like ChatGPT and Claude, turning your genome into a queryable knowledge base.

Two connection methods: JSON export (works with any AI) and MCP server (real-time queries, native in Claude).

The Helix MCP server provides seven tools: domain briefs, variant queries, PRS scores, pharmacogenomics, convergences, evidence, and inheritance analysis.

Your AI can answer specific questions about drug safety, disease risk, supplement needs, fitness optimization, and nutrition — all grounded in your actual genotype.

Coverage includes 3,550+ polygenic risk score models, 34 pharmacogenes, and 400,000+ ClinVar variant screenings.

Zero data retention. Raw DNA file is deleted after analysis. MCP access is controlled by a revocable API key.

Unlike closed genomics chatbots, Helix gives you the data layer and lets you bring your own AI assistant.